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Fig. 3. Lipofuscin in neurons of the human brain. The aging pigment is shown within (A and B) the cytoplasm of neurons in the inferior olivary nucleus (involved in motor coordination) [(A) and (B) are from adjacent sections]; (C) the hippocampus (involved in memory formation); and (D) a neuron in the substantia nigra (involved in motor control) (shown at high magnification). In (A), (C), and (D), autofluorescent lipofuscin is visualized under UV light. The sections have been counterstained with DAPI (blue). In (B), lipofuscin has been stained red with the periodic acid-Schiff staining method. Scale bars, 30 µm in (A), (B), and (C), 10 µm in (D).


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Science of Aging Knowledge Environment. ISSN 1539-6150