Sci. Aging Knowl. Environ., 13 August 2003
Vol. 2003, Issue 32, p. tr2
[DOI: 10.1126/sageke.2003.32.tr2]


Estrogen, Bone, and Osteoporosis

B. Lawrence Riggs

Mayo Clinic, Rochester, MN 55905, U.S.A. E-mail: riggs.lawrence{at};2003/32/tr2

Key Words: estrogen receptor • testosterone • paracrine cytokines • osteoclast • osteoblast • RANK

Abstract: Until 1995, scientists held five widely accepted pillars of belief about estrogen action in the skeleton. Since then, a sea change in conventional wisdom has swept away these five beliefs. This lecture reviews data that have proved them wrong--or at least incomplete--and describes the new paradigms that have emerged to replace them.



1. B. L. Riggs, S. Khosla, L. J. Melton III, Sex steroids and the construction and conservation of the adult skeleton. Endocr. Rev. 23, 279-302 (2003). [Abstract] [Full Text]

Citation: B. L. Riggs, Estrogen, Bone, and Osteoporosis. Sci. SAGE KE 2003 (32), tr2 (2003).

Science of Aging Knowledge Environment. ISSN 1539-6150