SAGE KE Bulletin Board

New paper on anti-Abeta antibody treatment

10 February 2005

Dietmar R. Thal

Comment on: Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid- associated neuritic dystrophy in PDAPP transgenic mice. J Clin Invest. 2005 Feb 1 ; 115(2):428-433

This paper denonstrates that neuritic changes in dystrophic neurites are reversible under anti-Abeta-antibodies. This finding supports the amyloid-hypothesis and confirms and extends the finding of Oddo et al. (Neuron. 2004 Aug 5;43(3):321-32) that tau changes in APP-PS1-tau triple transgenic mice are reversible after passive immunization with anti-Abeta antibodies.

The following link shows the discussion of this article at alzforum.org:

http://www.alzforum.org/pap/annotation.asp?powID=42698#{D079FEFA-F66B -4F38-AA2B-2C106B0D6E4B}



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