SAGE KE Bulletin Board

Anti-Aging Science

1 March 2002

Leonid Gavrilov

Dear Colleagues,

I thought that perhaps this scientific community may be interested to know about the existence of legitimate anti-aging studies published in reputable scientific journals by established researchers.

Here is a sample example of such studies (21 references). The terms like 'anti-aging' in the titles of the publications are highlighted in CAPITAL letters.

Cavallini G, Donati A, Gori Z, Pollera M, Bergamini E. The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of ANTI-AGEING food restriction. Exp Gerontol 2001 36(3):497-506

Hipkiss AR. Carnosine, a protective, ANTI-AGEING peptide? Int J Biochem Cell Biol 1998 30(8):863-8

Hipkiss AR, Brownson C. A possible new role for the ANTI-AGEING peptide carnosine. Cell Mol Life Sci 2000 57(5):747-53

Hipkiss AR, Brownson C. Carnosine reacts with protein carbonyl groups: another possible role for the ANTI-AGEING peptide? Biogerontology 2000;1(3):217-23

Hipkiss AR, Brownson C, Carrier MJ. Carnosine, the ANTI-AGEING, anti- oxidant dipeptide, may react with protein carbonyl groups. Mech Ageing Dev 2001 122(13):1431-45

Knook DL. ANTIAGING strategies. Ann. N. Y. Acad. Sci. 1992 663:372-5.

Lane MA, Baer DJ, Rumpler WV, Weindruch R, Ingram DK, Tilmont EM, Cutler RG, Roth GS Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated ANTI-AGING mechanism in rodents. Proceedings of the National Academy of Sciences of the United States of America 1996 93 (9): 4159-4164

Masoro EJ. Potential role of the modulation of fuel use in the ANTIAGING action of dietary restriction. Ann N Y Acad Sci 1992 663:403-11

Masoro EJ. ANTIAGING action of caloric restriction: endocrine and metabolic aspects. Obes Res 1995 3 Suppl 2:241s-247s

Masoro EJ. Possible mechanisms underlying the ANTIAGING actions of caloric restriction. Toxicol Pathol 1996 24(6):738-41

Masoro EJ. Hormesis and the ANTIAGING action of dietary restriction. Exp Gerontol 1998 33(1-2):61-6

Masoro EJ, Austad SN. The evolution of the ANTIAGING action of dietary restriction: a hypothesis. J Gerontol A Biol Sci Med Sci 1996 51(6):B387-91

Meites J. ANTI-AGEING interventions and their neuroendocrine aspects in mammals. J. Reprod. Fertil., Suppl 1993;46:1-9.

Moriguchi T, Saito H, Nishiyama N. ANTI-AGEING effect of aged garlic extract in the inbred brain atrophy mouse model. Clin. Exp. Pharmacol. Physiol. 1997 24(3-4):235-42

Norris CM, Halpain S, Foster TC. REVERSAL of age-related alterations in synaptic plasticity by blockade of L-type Ca2+ channels. J. Neurosci. 1998;18(9):3171-9.

Novelli M, Masiello P, Bombara M, Bergamini E. Protein glycation in the aging male Sprague-Dawley rat: effects of ANTIAGING diet restrictions. J Gerontol A Biol Sci Med Sci 1998 53(2):B94-101

Rattan SI. The nature of gerontogenes and vitagenes. ANTIAGING effects of repeated heat shock on human fibroblasts. Ann N Y Acad Sci 1998 854:54-60

Shimokawa I, Higami Y. A role for leptin in the ANTIAGING action of dietary restriction: a hypothesis. Aging (Milano) 1999 11(6):380-2.

Svendsen L, Rattan SI, Clark BF. Testing garlic for possible ANTI- AGING effects on long-term growth characteristics, morphology and macromolecular synthesis of human fibroblasts in culture. Ethnopharmacol 1994 43(2):125-33

Yu BP Approaches to ANTI-AGING intervention: the promises and the uncertainties. Mech Ageing Dev 1999 111 (2-3): 73-87

Van Remmen H, Guo Z, Richardson A. The ANTI-AGING action of dietary restriction. Novartis Found Symp 2001;235:221-30

For more information visit the following website:

Science of Aging Knowledge Environment. ISSN 1539-6150