Detailed, broad articles that review timely topics of interest; written by scientists.

Targeting the Role of the Endosome in the Pathophysiology of Alzheimer's Disease: A Strategy for Treatment   Alzheimer's disease-associated endosomal abnormalities might provide a route for drug-based interventions.  (28 June 2006)
Barbara A. Tate and Paul M. Mathews
Sci. Aging Knowl. Environ. 2006 (10), re2. [DOI: 10.1126/sageke.2006.10.re2]
[Abstract] [Full Text] [PDF]

The Development of Amyloid beta Protein Deposits in the Aged Brain   Different types of amyloid ß protein deposits offer clues into the development of neurodegeneration.  (8 March 2006)
Dietmar R. Thal, Estibaliz Capetillo-Zarate, Kelly Del Tredici, and Heiko Braak
Sci. Aging Knowl. Environ. 2006 (6), re1. [DOI: 10.1126/sageke.2006.6.re1]
[Abstract] [Full Text] [PDF] [Supporting Online Material]

More Reviews



Introductory reviews on key subjects that contain interview material; written by science journalists.

On Trial  Jumping from laboratory to human studies puts researchers to the test.  (16 June 2004)
R. John Davenport
Sci. Aging Knowl. Environ. 2004 (24), oa1. [DOI: 10.1126/sageke.2004.24.oa1]
[Abstract] [Full Text] [PDF]

Detangling Alzheimer's Disease  Toward better diagnostics and possible therapeutics.  (29 October 2003)
Laura Helmuth
Sci. SAGE KE 2003 (43), oa2. [DOI: 10.1126/sageke.2003.43.oa2]
[Abstract] [Full Text] [PDF] [What's New in This Update]

Immunity Challenge  The immune system falters with age, and researchers are beginning to understand why.  (11 June 2003)
R. John Davenport
Sci. SAGE KE 2003 (23), oa1. [DOI: 10.1126/sageke.2003.23.oa1]
[Abstract] [Full Text] [PDF]

The Burden of Pain on the Shoulders of Aging  When growing old hurts.  (18 December 2002)
Mary Beckman
Sci. SAGE KE 2002 (50), oa1. [DOI: 10.1126/sageke.2002.50.oa1]
[Abstract] [Full Text] [PDF]

The Two Faces of Oxygen  A good thing that might kill you.  (3 October 2001)
Rabiya Tuma
Sci. SAGE KE 2001 (1), oa5. [DOI: 10.1126/sageke.2001.1.oa5]
[Abstract] [Full Text] [PDF]

More Hot Topic Orientations



Patient histories and pathology reports; written by physicians.

Dementia with Cerebrovascular Disease  A case study.  (28 June 2006)
Clinton B. Wright, Jean Paul G. Vonsattel, Karen Bell, and Lawrence S. Honig
Sci. Aging Knowl. Environ. 2006 (10), dn1. [DOI: 10.1126/sageke.2006.10.dn1]
[Abstract] [Full Text]

Brain Tumor-Associated Dementia  A case study.  (24 August 2005)
James McC. Noble, Peter Canoll, and Lawrence S. Honig
Sci. Aging Knowl. Environ. 2005 (34), dn2. [DOI: 10.1126/sageke.2005.34.dn2]
[Abstract] [Full Text]

Dementia of the Alzheimer's Type and Accelerated Aging in Down Syndrome  A case study  (6 April 2005)
D. A. Devenny, J. Wegiel, N. Schupf, E. Jenkins, W. Zigman, S. J. Krinsky-McHale, and W. P. Silverman
Sci. Aging Knowl. Environ. 2005 (14), dn1. [DOI: 10.1126/sageke.2005.14.dn1]
[Abstract] [Full Text] [Supporting Online Material - Videos] [Supporting Online Material -- Tables]

Osteoarthritis  A case study.  (1 September 2004)
Najia Shakoor and Richard F. Loeser
Sci. Aging Knowl. Environ. 2004 (35), dn2. [DOI: 10.1126/sageke.2004.35.dn2]
[Abstract] [Full Text]

More Neurodegenerative Disease Case Studies

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