TRB3 Links the E3 Ubiquitin Ligase COP1 to Lipid Metabolism  (From Science).  (28 June 2006)
Ling Qi, Jose E. Heredia, Judith Y. Altarejos, Robert Screaton, Naomi Goebel, Sherry Niessen, Ian X. MacLeod, Chong Wee Liew, Rohit N. Kulkarni, James Bain, Christopher Newgard, Michael Nelson, Ronald M. Evans, John Yates, and Marc Montminy
Sci. Aging Knowl. Environ. 2006 (10), or16.
[Abstract/Full Text]

{alpha}-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models  (From Science).  (28 June 2006)
Antony A. Cooper, Aaron D. Gitler, Anil Cashikar, Cole M. Haynes, Kathryn J. Hill, Bhupinder Bhullar, Kangning Liu, Kexiang Xu, Katherine E. Strathearn, Fang Liu, Songsong Cao, Kim A. Caldwell, Guy A. Caldwell, Gerald Marsischky, Richard D. Kolodner, Joshua LaBaer, Jean-Christophe Rochet, Nancy M. Bonini, and Susan Lindquist
Sci. Aging Knowl. Environ. 2006 (10), or15.
[Abstract/Full Text]

Response to Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction"  (From Science).  (28 June 2006)
Dudley W. Lamming, Magda Latorre-Esteves, Oliver Medvedik, Stacy N. Wong, Felicia A. Tsang, Chen Wang, Su-Ju Lin, and David A. Sinclair
Sci. Aging Knowl. Environ. 2006 (10), or14.
[Abstract/Full Text]

Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction"   (From Science).  (28 June 2006)
Matt Kaeberlein, Kristan K. Steffen, Di Hu, Nick Dang, Emily O. Kerr, Mitsuhiro Tsuchiya, Stanley Fields, and Brian K. Kennedy
Sci. Aging Knowl. Environ. 2006 (10), or13.
[Abstract/Full Text]

Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans  (From Science).  (28 June 2006)
Anders Olsen, Maithili C. Vantipalli, and Gordon J. Lithgow
Sci. Aging Knowl. Environ. 2006 (10), or12.
[Abstract/Full Text]

Hypothalamic mTOR Signaling Regulates Food Intake  (From Science).  (24 May 2006)
Daniela Cota, Karine Proulx, Kathi A. Blake Smith, Sara C. Kozma, George Thomas, Stephen C. Woods, and Randy J. Seeley
Sci. Aging Knowl. Environ. 2006 (9), or11.
[Abstract/Full Text]

Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1{alpha}  (From Science).  (3 May 2006)
Claudio Hetz, Paula Bernasconi, Jill Fisher, Ann-Hwee Lee, Michael C. Bassik, Bruno Antonsson, Gabriel S. Brandt, Neal N. Iwakoshi, Anna Schinzel, Laurie H. Glimcher, and Stanley J. Korsmeyer
Sci. Aging Knowl. Environ. 2006 (8), or10.
[Abstract/Full Text]

Lamin A-Dependent Nuclear Defects in Human Aging   (From Science).  (3 May 2006)
Paola Scaffidi and Tom Misteli
Sci. Aging Knowl. Environ. 2006 (8), or9.
[Abstract/Full Text]

Fuel-Powered Artificial Muscles  (From Science).  (5 April 2006)
Von Howard Ebron, Zhiwei Yang, Daniel J. Seyer, Mikhail E. Kozlov, Jiyoung Oh, Hui Xie, Joselito Razal, Lee J. Hall, John P. Ferraris, Alan G. MacDiarmid, and Ray H. Baughman
Sci. Aging Knowl. Environ. 2006 (7), or8.
[Abstract/Full Text]

A Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria  (From Science).  (8 March 2006)
Loren G. Fong, David Frost, Margarita Meta, Xin Qiao, Shao H. Yang, Catherine Coffinier, and Stephen G. Young
Sci. Aging Knowl. Environ. 2006 (6), or7.
[Abstract/Full Text]

Mouse Study Suggests Cancer Drugs Could Help Prematurely Aging Kids   (From Science).  (8 March 2006)
John Travis
Sci. Aging Knowl. Environ. 2006 (6), or6.
[Abstract/Full Text]

Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis  (From Science).  (8 March 2006)
Saquib A. Lakhani, Ali Masud, Keisuke Kuida, George A. Porter Jr., Carmen J. Booth, Wajahat Z. Mehal, Irteza Inayat, and Richard A. Flavell
Sci. Aging Knowl. Environ. 2006 (6), or5.
[Abstract/Full Text]

Cellular Senescence in Aging Primates   (From Science).  (8 February 2006)
Utz Herbig, Mark Ferreira, Laura Condel, Dee Carey, and John M. Sedivy
Sci. Aging Knowl. Environ. 2006 (5), or4.
[Abstract/Full Text]

Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2   Finding might aid the development of anti-inflammatory drugs (From Science).  (4 January 2006)
Sangwon F. Kim, Daniel A. Huri, and Solomon H. Snyder
Sci. Aging Knowl. Environ. 2006 (1), or3.
[Abstract/Full Text]

A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans  (From Science).  (4 January 2006)
Michelle Boehm and Frank Slack
Sci. Aging Knowl. Environ. 2006 (1), or2.
[Abstract/Full Text]

The Tick-Tock of Aging?  (From Science).  (4 January 2006)
Adam Antebi
Sci. Aging Knowl. Environ. 2006 (1), or1.
[Abstract/Full Text]

Increase in Activity During Calorie Restriction Requires Sirt1  (From Science).  (14 December 2005)
Danica Chen, Andrew D. Steele, Susan Lindquist, and Leonard Guarente
Sci. Aging Knowl. Environ. 2005 (50), or22.
[Abstract/Full Text]

SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells  (From Science).  (30 November 2005)
Peter W. Reddien, Néstor J. Oviedo, Joya R. Jennings, James C. Jenkin, and Alejandro Sánchez Alvarado
Sci. Aging Knowl. Environ. 2005 (48), or21.
[Abstract/Full Text]

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients  (From Science).  (23 November 2005)
Matt Kaeberlein, R. Wilson Powers, III, Kristan K. Steffen, Eric A. Westman, Di Hu, Nick Dang, Emily O. Kerr, Kathryn T. Kirkland, Stanley Fields, and Brian K. Kennedy
Sci. Aging Knowl. Environ. 2005 (47), or20.
[Abstract/Full Text]

Twists in the Tale of the Aging Yeast   (From Science).  (23 November 2005)
Jasper Rine
Sci. Aging Knowl. Environ. 2005 (47), or19.
[Abstract/Full Text]

Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake  (From Science).  (16 November 2005)
Jian V. Zhang, Pei-Gen Ren, Orna Avsian-Kretchmer, Ching-Wei Luo, Rami Rauch, Cynthia Klein, and Aaron J. W. Hsueh
Sci. Aging Knowl. Environ. 2005 (46), or18.
[Abstract/Full Text]

Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance  (From Science).  (2 November 2005)
Maia V. Kokoeva, Huali Yin, and Jeffrey S. Flier
Sci. Aging Knowl. Environ. 2005 (44), or17.
[Abstract/Full Text]

The {beta}-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel   Potential antiaging hormone affects calcium channel activity (From Science).  (26 October 2005)
Q. Chang, S. Hoefs, A. W. van der Kemp, C. N. Topala, R. J. Bindels, and J. G. Hoenderop
Sci. Aging Knowl. Environ. 2005 (43), or16.
[Abstract/Full Text]

Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS  (From Science).  (19 October 2005)
Enzo Nisoli, Cristina Tonello, Annalisa Cardile, Valeria Cozzi, Renata Bracale, Laura Tedesco, Sestina Falcone, Alessandra Valerio, Orazio Cantoni, Emilio Clementi, Salvador Moncada, and Michele O. Carruba
Sci. Aging Knowl. Environ. 2005 (42), or15.
[Abstract/Full Text]

Keeping the Young from Dying Old  (From ScienceNow).  (31 August 2005)
John Travis
Sci. Aging Knowl. Environ. 2005 (35), or14.
[Abstract/Full Text]

Suppression of Aging in Mice by the Hormone Klotho  (From Science).  (31 August 2005)
Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark, Johanne V. Pastor, Animesh Nandi, Prem Gurnani, Owen P. McGuinness, Hirotaka Chikuda, Masayuki Yamaguchi, Hiroshi Kawaguchi, Iichiro Shimomura, Yoshiharu Takayama, Joachim Herz, C. Ronald Kahn, Kevin P. Rosenblatt, and Makoto Kuro-o
Sci. Aging Knowl. Environ. 2005 (35), or13.
[Abstract/Full Text]

Preventing Alzheimer's: A Lifelong Commitment?  (From Science).  (10 August 2005)
Jean Marx
Sci. Aging Knowl. Environ. 2005 (32), or12.
[Abstract/Full Text]

HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction  (From Science).  (3 August 2005)
Dudley W. Lamming, Magda Latorre-Esteves, Oliver Medvedik, Stacy N. Wong, Felicia A. Tsang, Chen Wang, Su-Ju Lin, and David A. Sinclair
Sci. Aging Knowl. Environ. 2005 (31), or11.
[Abstract/Full Text]

Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior  (From Science).  (27 July 2005)
Ignacio Flores, María L. Cayuela, and María A. Blasco
Sci. Aging Knowl. Environ. 2005 (30), or10.
[Abstract/Full Text]

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function  (From Science).  (20 July 2005)
K. SantaCruz, J. Lewis, T. Spires, J. Paulson, L. Kotilinek, M. Ingelsson, A. Guimaraes, M. DeTure, M. Ramsden, E. McGowan, C. Forster, M. Yue, J. Orne, C. Janus, A. Mariash, M. Kuskowski, B. Hyman, M. Hutton, and K. H. Ashe
Sci. Aging Knowl. Environ. 2005 (29), or9.
[Abstract/Full Text]

Patient-Specific Embryonic Stem Cells Derived from Human SCNT Blastocysts  (From Science).  (25 May 2005)
Woo Suk Hwang, Sung Il Roh, Byeong Chun Lee, Sung Keun Kang, Dae Kee Kwon, Sue Kim, Sun Jong Kim, Sun Woo Park, Hee Sun Kwon, Chang Kyu Lee, Jung Bok Lee, Jin Mee Kim, Curie Ahn, Sun Ha Paek, Sang Sik Chang, Jung Jin Koo, Hyun Soo Yoon, Jung Hye Hwang, Youn Young Hwang, Ye Soo Park, Sun Kyung Oh, Hee Sun Kim, Jong Hyuk Park, Shin Yong Moon, and Gerald Schatten
Sci. Aging Knowl. Environ. 2005 (21), or8.
[Abstract/Full Text]

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria  (From Science).  (11 May 2005)
Samuel E. Schriner, Nancy J. Linford, George M. Martin, Piper Treuting, Charles E. Ogburn, Mary Emond, Pinar E. Coskun, Warren Ladiges, Norman Wolf, Holly Van Remmen, Douglas C. Wallace, and Peter S. Rabinovitch
Sci. Aging Knowl. Environ. 2005 (19), or7.
[Abstract/Full Text]

Complement Factor H Polymorphism in Age-Related Macular Degeneration  (From Science).  (16 March 2005)
Robert J. Klein, Caroline Zeiss, Emily Y. Chew, Jen-Yue Tsai, Richard S. Sackler, Chad Haynes, Alice K. Henning, John Paul SanGiovanni, Shrikant M. Mane, Susan T. Mayne, Michael B. Bracken, Frederick L. Ferris, Jurg Ott, Colin Barnstable, and Josephine Hoh
Sci. Aging Knowl. Environ. 2005 (11), or6.
[Abstract/Full Text]

Complement Factor H Polymorphism and Age-Related Macular Degeneration  (From Science).  (16 March 2005)
Albert O. Edwards, Robert Ritter III, Kenneth J. Abel, Alisa Manning, Carolien Panhuysen, and Lindsay A. Farrer
Sci. Aging Knowl. Environ. 2005 (11), or5.
[Abstract/Full Text]

Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration  (From Science).  (16 March 2005)
Jonathan L. Haines, Michael A. Hauser, Silke Schmidt, William K. Scott, Lana M. Olson, Paul Gallins, Kylee L. Spencer, Shu Ying Kwan, Maher Noureddine, John R. Gilbert, Nathalie Schnetz-Boutaud, Anita Agarwal, Eric A. Postel, and Margaret A. Pericak-Vance
Sci. Aging Knowl. Environ. 2005 (11), or4.
[Abstract/Full Text]

Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance  (From Science).  (9 February 2005)
Xin Jie Chen, Xiaowen Wang, Brett A. Kaufman, and Ronald A. Butow
Sci. Aging Knowl. Environ. 2005 (6), or3.
[Abstract/Full Text]

Self-Propagating, Molecular-Level Polymorphism in Alzheimer's {beta}-Amyloid Fibrils  (From Science).  (19 January 2005)
Aneta T. Petkova, Richard D. Leapman, Zhihong Guo, Wai-Ming Yau, Mark P. Mattson, and Robert Tycko
Sci. Aging Knowl. Environ. 2005 (3), or2.
[Abstract/Full Text]

Anticonvulsant Medications Extend Worm Life-Span  Results suggest that neural activity regulates aging (From Science).  (19 January 2005)
Kimberley Evason, Cheng Huang, Idella Yamben, Douglas F. Covey, and Kerry Kornfeld
Sci. Aging Knowl. Environ. 2005 (3), or1.
[Abstract/Full Text]

Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway  (From Science).  (22 December 2004)
Shino Nemoto, Maria M. Fergusson, and Toren Finkel
Sci. Aging Knowl. Environ. 2004 (51), or24.
[Abstract/Full Text]

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin  (From Science).  (22 December 2004)
Atsunori Fukuhara, Morihiro Matsuda, Masako Nishizawa, Katsumori Segawa, Masaki Tanaka, Kae Kishimoto, Yasushi Matsuki, Mirei Murakami, Tomoko Ichisaka, Hiroko Murakami, Eijiro Watanabe, Toshiyuki Takagi, Megumi Akiyoshi, Tsuguteru Ohtsubo, Shinji Kihara, Shizuya Yamashita, Makoto Makishima, Tohru Funahashi, Shinya Yamanaka, Ryuji Hiramatsu, Yuji Matsuzawa, and Iichiro Shimomura
Sci. Aging Knowl. Environ. 2004 (51), or23.
[Abstract/Full Text]

Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity  Loss of telomeres from single sister chromatids occurs in Werner syndrome cells. (From Science).  (15 December 2004)
Laure Crabbe, Ramiro E. Verdun, Candy I. Haggblom, and Jan Karlseder
Sci. Aging Knowl. Environ. 2004 (50), or22.
[Abstract/Full Text]

Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis  (From Science).  (1 December 2004)
Romeo Ricci, Grzegorz Sumara, Izabela Sumara, Izabela Rozenberg, Michael Kurrer, Alexander Akhmedov, Martin Hersberger, Urs Eriksson, Franz R. Eberli, Burkhard Becher, Jan Borén, Mian Chen, Myron I. Cybulsky, Kathryn J. Moore, Mason W. Freeman, Erwin F. Wagner, Christian M. Matter, and Thomas F. Lüscher
Sci. Aging Knowl. Environ. 2004 (48), or21.
[Abstract/Full Text]

COX-2 Derived Prostacyclin Confers Atheroprotection on Female Mice  Inhibitors of COX-2 might increase the susceptibility of premenopausal females to cardiovascular disease. (From Science).  (24 November 2004)
Karine M. Egan, John A. Lawson, Susanne Fries, Beverley Koller, Daniel J. Rader, Emer M. Smyth, and Garret A. FitzGerald
Sci. Aging Knowl. Environ. 2004 (47), or20.
[Abstract/Full Text]

Harnessing Chaperones to Generate Small-Molecule Inhibitors of Amyloid {beta} Aggregation  (From Science).  (3 November 2004)
Jason E. Gestwicki, Gerald R. Crabtree, and Isabella A. Graef
Sci. Aging Knowl. Environ. 2004 (44), or19.
[Abstract/Full Text]

A Cluster of Metabolic Defects Caused by Mutation in a Mitochondrial tRNA  Finding might have implications for understanding why hypertension and dyslipidemia often occur together. (From Science).  (27 October 2004)
Frederick H. Wilson, Ali Hariri, Anita Farhi, Hongyu Zhao, Kitt Falk Petersen, Hakan R. Toka, Carol Nelson-Williams, Khalid M. Raja, Michael Kashgarian, Gerald I. Shulman, Steven J. Scheinman, and Richard P. Lifton
Sci. Aging Knowl. Environ. 2004 (43), or18.
[Abstract/Full Text]

Inflammatory Exposure and Historical Changes in Human Life-Spans  Reduced inflammation early in life might result in decreased mortality in old age. (From Science).  (22 September 2004)
Caleb E. Finch and Eileen M. Crimmins
Sci. Aging Knowl. Environ. 2004 (38), or17.
[Abstract/Full Text]

Living with the Past: Evolution, Development, and Patterns of Disease  The risk of developing certain chronic diseases in adulthood might be affected by environmental influences early in life. (From Science).  (22 September 2004)
Peter D. Gluckman and Mark A. Hanson
Sci. Aging Knowl. Environ. 2004 (38), or16.
[Abstract/Full Text]

Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration  (From Science).  (18 August 2004)
Toshiyuki Araki, Yo Sasaki, and Jeffrey Milbrandt
Sci. Aging Knowl. Environ. 2004 (33), or15.
[Abstract/Full Text]

NAD to the Rescue  (From Science).  (18 August 2004)
Antonio Bedalov and Julian A. Simon
Sci. Aging Knowl. Environ. 2004 (33), or14.
[Abstract/Full Text]

Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body  Transcription factor lengthens life span and slashes fecundity in female flies. (From Science).  (16 June 2004)
Maria E. Giannakou, Martin Goss, Martin A. Jünger, Ernst Hafen, Sally J. Leevers, and Linda Partridge
Sci. Aging Knowl. Environ. 2004 (24), or13.
[Abstract/Full Text]

Locating a New Step in Pain's Pathway  (From Science).  (12 May 2004)
Jean Marx
Sci. Aging Knowl. Environ. 2004 (19), or12.
[Abstract/Full Text]

S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function  New research reveals links between parkin modification, ubiquitination, and neurodegeneration. (From Science).  (28 April 2004)
Kenny K. K. Chung, Ted M. Dawson, Bobby Thomas, Xiaojie Li, Olga Pletnikova, Juan C. Troncoso, Laura Marsh, and Valina L. Dawson
Sci. Aging Knowl. Environ. 2004 (17), or11.
[Abstract/Full Text]

Renovating the Heart  (From Science).  (21 April 2004)
Jennifer Couzin and Gretchen Vogel
Sci. Aging Knowl. Environ. 2004 (16), or10.
[Abstract/Full Text]

ABAD Directly Links A{beta} to Mitochondrial Toxicity in Alzheimer's Disease  (From Science).  (21 April 2004)
Joyce W. Lustbader, Maurizio Cirilli, Chang Lin, Hong Wei Xu, Kazuhiro Takuma, Ning Wang, Casper Caspersen, Xi Chen, Susan Pollak, Michael Chaney, Fabrizio Trinchese, Shumin Liu, Frank Gunn-Moore, Lih-Fen Lue, Douglas G. Walker, Periannan Kuppusamy, Zay L. Zewier, Ottavio Arancio, David Stern, Shirley ShiDu Yan, and Hao Wu
Sci. Aging Knowl. Environ. 2004 (16), or9.
[Abstract/Full Text]

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1  (From Science).  (21 April 2004)
Enza Maria Valente, Patrick M. Abou-Sleiman, Viviana Caputo, Miratul M. K. Muqit, Kirsten Harvey, Suzana Gispert, Zeeshan Ali, Domenico Del Turco, Anna Rita Bentivoglio, Daniel G. Healy, Alberto Albanese, Robert Nussbaum, Rafael González-Maldonado, Thomas Deller, Sergio Salvi, Pietro Cortelli, William P. Gilks, David S. Latchman, Robert J. Harvey, Bruno Dallapiccola, Georg Auburger, and Nicholas W. Wood
Sci. Aging Knowl. Environ. 2004 (16), or8.
[Abstract/Full Text]

Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells  It's not the vascular smooth muscle cells that enhance neuron production. (From Science).  (7 April 2004)
Qin Shen, Susan Goderie, Li Jin, Nithin Karanth, Yu Sun, Natalie Abramova, Peter Vincent, Kevin Pumiglia, and Sally Temple
Sci. Aging Knowl. Environ. 2004 (14), or7.
[Abstract/Full Text]

Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation  Translational repressor prevents precocious entry into oogenesis. (From Science).  (31 March 2004)
Zhong Wang and Haifan Lin
Sci. Aging Knowl. Environ. 2004 (13), or6.
[Abstract/Full Text]

Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice  (From Science).  (24 March 2004)
Jonathan B. Singer, Annie E. Hill, Lindsay C. Burrage, Keith R. Olszens, Junghan Song, Monica Justice, William E. O'Brien, David V. Conti, John S. Witte, Eric S. Lander, and Joseph H. Nadeau
Sci. Aging Knowl. Environ. 2004 (12), or5.
[Abstract/Full Text]

Aging Research's Family Feud  (From Science).  (3 March 2004)
Jennifer Couzin
Sci. Aging Knowl. Environ. 2004 (9), or4.
[Abstract/Full Text]

Is Biomedical Research Too Dangerous to Pursue?  One bioethicist says no. (From Science).  (25 February 2004)
Arthur Caplan
Sci. Aging Knowl. Environ. 2004 (8), or3.
[Abstract/Full Text]

Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase  Insulin signaling pathway sensors influence longevity in mammals. (From Science).  (25 February 2004)
Anne Brunet, Lora B. Sweeney, J. Fitzhugh Sturgill, Katrin F. Chua, Paul L. Greer, Yingxi Lin, Hien Tran, Sarah E. Ross, Raul Mostoslavsky, Haim Y. Cohen, Linda S. Hu, Hwei-Ling Cheng, Mark P. Jedrychowski, Steven P. Gygi, David A. Sinclair, Frederick W. Alt, and Michael E. Greenberg
Sci. Aging Knowl. Environ. 2004 (8), or2.
[Abstract/Full Text]

Respect Thy Neighbor!  Tissue microenvironment alters surrounding tumor cells. (From Science).  (11 February 2004)
Derek C. Radisky and Mina J. Bissell
Sci. Aging Knowl. Environ. 2004 (6), or1.
[Abstract/Full Text]

Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or Alpha-Synuclein  (From Science).  (10 December 2003)
Stephen Willingham, Tiago Fleming Outeiro, Michael J. DeVit, Susan L. Lindquist, and Paul J. Muchowski
Sci. Aging Knowl. Environ. 2003 (49), or31.
[Abstract/Full Text]

Insulin Signaling in Health and Disease  (From Science).  (10 December 2003)
Morris F. White
Sci. Aging Knowl. Environ. 2003 (49), or30.
[Abstract/Full Text]

Redox Regulation of Germline and Vulval Development in Caenorhabditis elegans  (From Science).  (10 December 2003)
Yukimasa Shibata, Robyn Branicky, Irene Oviedo Landaverde, and Siegfried Hekimi
Sci. Aging Knowl. Environ. 2003 (49), or29.
[Abstract/Full Text]

Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology  (From Science).  (10 December 2003)
Tiago Fleming Outeiro and Susan Lindquist
Sci. Aging Knowl. Environ. 2003 (49), or28.
[Abstract/Full Text]

Brain Researchers Try to Salvage Estrogen Treatments  (From Science).  (19 November 2003)
Ingrid Wickelgren
Sci. Aging Knowl. Environ. 2003 (46), or27.
[Abstract/Full Text]

The Great Estrogen Conundrum  (From Science).  (19 November 2003)
Jennifer Couzin
Sci. Aging Knowl. Environ. 2003 (46), or26.
[Abstract/Full Text]

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis  Common nonsteroidal anti-inflammatory drug reverses damage caused by neuroinflammation. (From Science).  (19 November 2003)
Michelle L. Monje, Hiroki Toda, and Theo D. Palmer
Sci. Aging Knowl. Environ. 2003 (46), or25.
[Abstract/Full Text]

Yeast Life Span Extension by Calorie Restriction Is Independent of NAD Fluctuation  Alterations in cofactor concentrations don't affect Sir2 deacetylase activity. (From Science).  (12 November 2003)
Rozalyn M. Anderson, Magda Latorre-Esteves, Ana Rute Neves, Siva Lavu, Oliver Medvedik, Christopher Taylor, Konrad T. Howitz, Helena Santos, and David A. Sinclair
Sci. Aging Knowl. Environ. 2003 (45), or24.
[Abstract/Full Text]

{alpha}-Synuclein Locus Triplication Causes Parkinson's Disease  SNCA triplication segregates with parkinsonism but not postural tremor. (From Science).  (5 November 2003)
A. B. Singleton, M. Farrer, J. Johnson, A. Singleton, S. Hague, J. Kachergus, M. Hulihan, T. Peuralinna, A. Dutra, R. Nussbaum, S. Lincoln, A. Crawley, M. Hanson, D. Maraganore, C. Adler, M. R. Cookson, M. Muenter, M. Baptista, D. Miller, J. Blancato, J. Hardy, and K. Gwinn-Hardy
Sci. Aging Knowl. Environ. 2003 (44), or23.
[Abstract/Full Text]

CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity  (From Science).  (8 October 2003)
Giovanni Marsicano, Sharon Goodenough, Krisztina Monory, Heike Hermann, Matthias Eder, Astrid Cannich, Shahnaz C. Azad, Maria Grazia Cascio, Silvia Ortega Gutiérrez, Mario van der Stelt, Maria Luz López-Rodríguez, Emilio Casanova, Günther Schütz, Walter Zieglgänsberger, Vincenzo Di Marzo, Christian Behl, and Beat Lutz
Sci. SAGE KE 2003 (40), or22.
[Abstract/Full Text]

Untangling Desmosomal Knots with Electron Tomography  (From Science).  (8 October 2003)
Wanzhong He, Pamela Cowin, and David L. Stokes
Sci. SAGE KE 2003 (40), or21.
[Abstract/Full Text]

Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice  (From Science).  (8 October 2003)
A. M. Clement, M. D. Nguyen, E. A. Roberts, M. L. Garcia, S. Boillée, M. Rule, A. P. McMahon, W. Doucette, D. Siwek, R. J. Ferrante, R. H. Brown Jr., J.-P. Julien, L. S. B. Goldstein, and D. W. Cleveland
Sci. SAGE KE 2003 (40), or20.
[Abstract/Full Text]

An Age-Induced Switch to a Hyper-Recombinational State  Scientists use yeast to study genomic instability as a function of age. (From Science).  (1 October 2003)
Michael A. McMurray and Daniel E. Gottschling
Sci. SAGE KE 2003 (39), or19.
[Abstract/Full Text]

An Age of Instability  The increase in genetic instability in aging yeast cells is independent of life span determination. (From Science).  (1 October 2003)
David A. Sinclair
Sci. SAGE KE 2003 (39), or18.
[Abstract/Full Text]

It's Never Too Late  Following a restricted diet during the golden years extends longevity. (From Science).  (24 September 2003)
James W. Vaupel, James R. Carey, and Kaare Christensen
Sci. SAGE KE 2003 (38), or17.
[Abstract/Full Text]

Transcriptional Repression of Atherogenic Inflammation: Modulation by PPAR{delta}  Deletion of PPAR{delta} from lipid-laden macrophages reduces atherosclerotic lesions. (From Science).  (17 September 2003)
Chih-Hao Lee, Ajay Chawla, Ned Urbiztondo, Debbie Liao, William A. Boisvert, and Ronald M. Evans
Sci. SAGE KE 2003 (37), or16.
[Abstract/Full Text]

Autophagy Genes Are Essential for Dauer Development and Life Span Extension in C. elegans  Life span extension and dauer development require autophagy. (From Science).  (10 September 2003)
Alicia Meléndez, Zsolt Tallóczy, Matthew Seaman, Eeva-Liisa Eskelinen, David H. Hall, and Beth Levine
Sci. SAGE KE 2003 (36), or15.
[Abstract/Full Text]

Possible Role for Environmental Copper in Alzheimer's Disease  (From Science).  (20 August 2003)
Jean Marx
Sci. SAGE KE 2003 (33), or14.
[Abstract/Full Text]

Drug Deals Diabetes a One-Two Punch  (From Science).  (23 July 2003)
Jennifer Couzin
Sci. SAGE KE 2003 (29), or13.
[Abstract/Full Text]

Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a  (From Science).  (16 July 2003)
Diego H. Castrillon, Lili Miao, Ramya Kollipara, James W. Horner, and Ronald A. DePinho
Sci. SAGE KE 2003 (28), or12.
[Abstract/Full Text]

Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance  (From Science).  (2 July 2003)
Kitt Falk Petersen, Douglas Befroy, Sylvie Dufour, James Dziura, Charlotte Ariyan, Douglas L. Rothman, Loretta DiPietro, Gary W. Cline, and Gerald I. Shulman
Sci. SAGE KE 2003 (26), or11.
[Abstract/Full Text]

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor  (From Science).  (2 July 2003)
Ao-Lin Hsu, Coleen T. Murphy, and Cynthia Kenyon
Sci. SAGE KE 2003 (26), or10.
[Abstract/Full Text]

Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens   Antimicrobial and anti-aging might go hand in hand. (From Science).  (25 June 2003)
Danielle A. Garsin, Jacinto M. Villanueva, Jakob Begun, Dennis H. Kim, Costi D. Sifri, Stephen B. Calderwood, Gary Ruvkun, and Frederick M. Ausubel
Sci. SAGE KE 2003 (25), or9.
[Abstract/Full Text]

Senescence in a Bacterium with Asymmetric Division   For senescence to evolve, asymmetry is key. (From Science).  (25 June 2003)
Martin Ackermann, Stephen C. Stearns, and Urs Jenal
Sci. SAGE KE 2003 (25), or8.
[Abstract/Full Text]

Old Neurons Revisit Their Youth  GABA restores sensory function in mature monkeys. (From Science).  (7 May 2003)
Greg Miller
Sci. SAGE KE 2003 (18), or7.
[Abstract/Full Text]

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein  Coincubation of proteins synergistically promotes amyloid fibril production in vitro. (From Science).  (7 May 2003)
Benoit I. Giasson, Mark S. Forman, Makoto Higuchi, Lawrence I. Golbe, Charles L. Graves, Paul T. Kotzbauer, John Q. Trojanowski, and Virginia M.-Y. Lee
Sci. SAGE KE 2003 (18), or6.
[Abstract/Full Text]

Lamin A Truncation in Hutchinson-Gilford Progeria  Long-sought mutation leads to loss of lamin A expression. (From Science).  (7 May 2003)
Annachiara De Sandre-Giovannoli, Rafaëlle Bernard, Pierre Cau, Claire Navarro, Jeanne Amiel, Irène Boccaccio, Stanislas Lyonnet, Colin L. Stewart, Arnold Munnich, Martine Le Merrer, and Nicolas Lévy
Sci. SAGE KE 2003 (18), or5.
[Abstract/Full Text]

Europe's Population at a Turning Point  If the low birthrate trend continues, the number of inhabitants of the Continent will shrink significantly. (From Science).  (2 April 2003)
Wolfgang Lutz, Brian C. O'Neill, and Sergei Scherbov
Sci. SAGE KE 2003 (13), or4.
[Abstract/Full Text]

A Matter of Life or Death  New insight into causes of blindness. (From Science).  (19 March 2003)
Rama Ranganathan
Sci. SAGE KE 2003 (11), or3.
[Abstract/Full Text]

Drosophila BLM in Double-Strand Break Repair by Synthesis-Dependent Strand Annealing  Blm blocks patching by error-prone pathways. (From Science).  (15 January 2003)
M. D. Adams, M. McVey, and J. J. Sekelsky
Sci. SAGE KE 2003 (2), or2.
[Abstract/Full Text]

Newborn Neurons Search for Meaning  Scientists have established that these cells exist--but no one's sure what they do. (From Science).  (8 January 2003)
Marcia Barinaga
Sci. SAGE KE 2003 (1), or1.
[Abstract/Full Text]

Sex Differences in Mortality Rate  Men more susceptible than women to parasite-induced death. (From Science).  (25 September 2002)
Ian P. F. Owens
Sci. SAGE KE 2002 (38), or12.
[Abstract/Full Text]

A Cinderella Caspase Takes Center Stage  Caspase-2 has a starring role in triggering apoptosis. (From Science).  (28 August 2002)
Sharad Kumar and David L. Vaux
Sci. SAGE KE 2002 (34), or11.
[Abstract/Full Text]

Protecting the Brain While Killing Pain?  An aspirin a day might keep Alzheimer's away. (From Science).  (28 August 2002)
Laura Helmuth
Sci. SAGE KE 2002 (34), or10.
[Abstract/Full Text]

New Alzheimer's Treatments That May Ease the Mind  As researchers come to better understand their foe, they're devising more means of attacking it. (From Science).  (28 August 2002)
Laura Helmuth
Sci. SAGE KE 2002 (34), or9.
[Abstract/Full Text]

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics  (From Science).  (24 July 2002)
John Hardy and Dennis J. Selkoe
Sci. SAGE KE 2002 (29), or8.
[Abstract/Full Text]

A Generation Gap in Brain Activity  As we age, we're no longer in our right hemisphere. (From Science).  (26 June 2002)
Laura Helmuth
Sci. SAGE KE 2002 (25), or7.
[Abstract/Full Text]

Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2  Response to hypoxia shares signaling components with pathways governing stress resistance and life-span determination. (From Science).  (19 June 2002)
Barbara A. Scott, Michael S. Avidan, and C. Michael Crowder
Sci. SAGE KE 2002 (24), or6.
[Abstract/Full Text]

Premature Aging in Mice Deficient in DNA Repair and Transcription  Support for the DNA damage accumulation hypothesis. (From Science).  (17 April 2002)
Jan de Boer, Jaan Olle Andressoo, Jan de Wit, Jan Huijmans, Rudolph B. Beems, Harry van Steeg, Geert Weeda, Gijsbertus T. J. van der Horst, Wibeke van Leeuwen, Axel P. N. Themmen, Morteza Meradji, and Jan H. J. Hoeijmakers
Sci. SAGE KE 2002 (15), or5.
[Abstract/Full Text]

Protein Structure: Harmless Proteins Twist Into Troublemakers  (From Science).  (10 April 2002)
Jennifer Couzin
Sci. SAGE KE 2002 (14), or4.
[Abstract/Full Text]

Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway  Disparate findings come together. (From Science).  (13 March 2002)
Shino Nemoto and Toren Finkel
Sci. SAGE KE 2002 (10), or3.
[Abstract/Full Text]

Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans  (From Science).  (23 January 2002)
Nuno Arantes-Oliveira, Javier Apfeld, Andrew Dillin, and Cynthia Kenyon
Sci. SAGE KE 2002 (3), or2.
[Abstract/Full Text]

Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q  (From Science).  (9 January 2002)
Pamela L. Larsen and Catherine F. Clarke
Sci. SAGE KE 2002 (1), or1.
[Abstract/Full Text]

ATR and ATRIP: Partners in Checkpoint Signaling  (From Science).  (28 November 2001)
David Cortez, Saritha Guntuku, Jun Qin, and Stephen J. Elledge
Sci. SAGE KE 2001 (9), or25.
[Abstract/Full Text]

A DNA Microarray-Based Genetic Screen for Nonhomologous End Joining Mutants in Saccharomyces cerevisiae  Seek and ye shall find new pathway components. (From Science).  (14 November 2001)
Siew Loon Ooi, Daniel D. Shoemaker, and Jef D. Boeke
Sci. SAGE KE 2001 (7), or24.
[Abstract/Full Text]

CNS Synaptogenesis Promoted by Glia-Derived Cholesterol  Much-maligned molecules promote mature synapse formation. (From Science).  (14 November 2001)
Daniela H. Mauch, Karl N�gler, Stefan Schumacher, Christian G�ritz, Eva-Christina M�ller, Albrecht Otto, and Frank W. Pfrieger
Sci. SAGE KE 2001 (7), or23.
[Abstract/Full Text]

Kinetic Stabilization of the {alpha}-Synuclein Protofibril by a Dopamine-{alpha}-Synuclein Adduct  Inhibitors of adduct formation might constitute a novel therapy for Parkinson's disease. (From Science).  (14 November 2001)
Kelly A. Conway, Jean-Christophe Rochet, Robert M. Bieganski, and Peter T. Lansbury Jr.
Sci. SAGE KE 2001 (7), or22.
[Abstract/Full Text]

Dopamine May Sustain Toxic Protein  (From Science).  (14 November 2001)
Jennifer Couzin
Sci. SAGE KE 2001 (7), or21.
[Abstract/Full Text]

Dopamine's Reversal of Fortune  Transporters pull double duty. (From Science).  (10 October 2001)
Randy D. Blakely
Sci. SAGE KE 2001 (2), or20.
[Abstract/Full Text]

Strand-Specific Postreplicative Processing of Mammalian Telomeres  A telomere is not a telomere is not a telomere. (From Science).  (10 October 2001)
P S. M. Bailey, M. N. Cornforth, A. Kurimasa, D. J. Chen, and E. H. Goodwin
Sci. SAGE KE 2001 (2), or19.
[Abstract/Full Text]

Trans-Suppression of Misfolding in an Amyloid Disease  Stabilizing subunits may protect against amyloidosis. (From Science).  (10 October 2001)
Per Hammarstr�m, Frank Schneider, and Jeffery W. Kelly
Sci. SAGE KE 2001 (2), or18.
[Abstract/Full Text]

DNA Ends RecQ-uire Attention  Helicase defects spur cancer and premature-aging syndromes. (From Science).  (10 October 2001)
Leonard Wu and Ian D. Hickson
Sci. SAGE KE 2001 (2), or17.
[Abstract/Full Text]

Hints of a "Master Gene" for Extreme Old Age  Blasting past 90 with a genetic booster rocket? (From Science).  (10 October 2001)
Evelyn Strauss
Sci. SAGE KE 2001 (2), or16.
[Abstract/Full Text]

Human DNA Repair Genes  A panoply of proteins protects DNA. (From Science).  (10 October 2001)
Richard D. Wood, Michael Mitchell, John Sgouros, and Tomas Lindahl
Sci. SAGE KE 2001 (2), or15.
[Abstract/Full Text]

Growing Old Together  Common processes control life-span in model organisms. (From Science).  (10 October 2001)
Evelyn Strauss
Sci. SAGE KE 2001 (2), or14.
[Abstract/Full Text]

Do Mitochondrial Mutations Dim the Fire of Life?  Pulling the plug on the cell's power plant. (From Science).  (10 October 2001)
Elizabeth Pennisi
Sci. SAGE KE 2001 (2), or13.
[Abstract/Full Text]

Parkin and Its Substrates  Toxic {alpha}-synuclein aggregates in Parkinson's disease. (From Science).  (10 October 2001)
Christian Haass and Philipp J. Kahle
Sci. SAGE KE 2001 (2), or12.
[Abstract/Full Text]

Tauists and {beta}aptists United--Well Almost  Plaques might trigger tangles in Alzheimer's disease. (From Science).  (10 October 2001)
Virginia M.-Y. Lee
Sci. SAGE KE 2001 (2), or11.
[Abstract/Full Text]

Sardinia's Mysterious Male Methuselahs  La Dolce Vita. (From Science).  (10 October 2001)
Robert Koenig
Sci. SAGE KE 2001 (2), or10.
[Abstract/Full Text]

Aging, Chromatin, and Food Restriction  Connecting the dots. (From Science).  (10 October 2001)
Judith Campisi
Sci. SAGE KE 2001 (2), or9.
[Abstract/Full Text]

A Portrait of Alzheimer Secretases  New Features and Familiar Faces. (From Science).  (10 October 2001)
William P. Esler and Michael S. Wolfe
Sci. SAGE KE 2001 (2), or8.
[Abstract/Full Text]

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikk{beta}  Insulin makes an inflammatory mark. (From Science).  (3 October 2001)
Minsheng Yuan, Nicky Konstantopoulos, Jongsoon Lee, Lone Hansen, Zhi-Wei Li, Michael Karin, and Steven E. Shoelson
Sci. SAGE KE 2001 (1), or7.
[Abstract/Full Text]

A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function  Short flies, long lives. (From Science).  (3 October 2001)
M. Tatar, A. Kopelman, D. Epstein, M.-P. Tu, C.-M. Yin, and R. S. Garofalo
Sci. SAGE KE 2001 (1), or6.
[Abstract/Full Text]

Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila  Genetic caloric restriction? (From Science).  (3 October 2001)
Blanka Rogina, Robert A. Reenan, Steven P. Nilsen, and Stephen L. Helfand
Sci. SAGE KE 2001 (1), or5.
[Abstract/Full Text]

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP  Oh what a tangled web is weaved. (From Science).  (3 October 2001)
Jada Lewis, Dennis W. Dickson, Wen-Lang Lin, Louise Chisholm, Anthony Corral, Graham Jones, Shu-Hui Yen, Naruhiko Sahara, Lisa Skipper, Debra Yager, Chris Eckman, John Hardy, Mike Hutton, and Eileen McGowan
Sci. SAGE KE 2001 (1), or4.
[Abstract/Full Text]

Regulation of Longevity and Stress Resistance by Sch9 in Yeast  Rising to the challenges of old age. (From Science).  (3 October 2001)
Paola Fabrizio, Fabiola Pozza, Scott D. Pletcher, Christi M. Gendron, and Valter D. Longo
Sci. SAGE KE 2001 (1), or3.
[Abstract/Full Text]

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by A{beta}42 Fibrils  It takes 42 to tangle. (From Science).  (3 October 2001)
J. G�tz, F. Chen, J. van Dorpe, and R. M. Nitsch
Sci. SAGE KE 2001 (1), or2.
[Abstract/Full Text]

Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein  A long-term buzz. (From Science).  (3 October 2001)
David J. Clancy, David Gems, Lawrence G. Harshman, Sean Oldham, Hugo Stocker, Ernst Hafen, Sally J. Leevers, and Linda Partridge
Sci. SAGE KE 2001 (1), or1.
[Abstract/Full Text]



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