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TRB3 Links the E3 Ubiquitin Ligase COP1 to Lipid Metabolism
(From Science).
(28 June 2006)
Ling Qi, Jose E. Heredia, Judith Y. Altarejos, Robert Screaton, Naomi Goebel, Sherry Niessen, Ian X. MacLeod, Chong Wee Liew, Rohit N. Kulkarni, James Bain, Christopher Newgard, Michael Nelson, Ronald M. Evans, John Yates, and Marc Montminy Sci. Aging Knowl. Environ. 2006 (10), or16. [Abstract/Full Text]
Response to Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction"
(From Science).
(28 June 2006)
Comment on "HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction"
(From Science).
(28 June 2006)
Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans
(From Science).
(28 June 2006)
Hypothalamic mTOR Signaling Regulates Food Intake
(From Science).
(24 May 2006)
Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1
Lamin A-Dependent Nuclear Defects in Human Aging
(From Science).
(3 May 2006)
Fuel-Powered Artificial Muscles
(From Science).
(5 April 2006)
A Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria
(From Science).
(8 March 2006)
Mouse Study Suggests Cancer Drugs Could Help Prematurely Aging Kids
(From Science).
(8 March 2006)
Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis
(From Science).
(8 March 2006)
Cellular Senescence in Aging Primates
(From Science).
(8 February 2006)
Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2
Finding might aid the development of anti-inflammatory drugs (From Science).
(4 January 2006)
A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans
(From Science).
(4 January 2006)
The Tick-Tock of Aging?
(From Science).
(4 January 2006)
Increase in Activity During Calorie Restriction Requires Sirt1
(From Science).
(14 December 2005)
SMEDWI-2 Is a PIWI-Like Protein That Regulates Planarian Stem Cells
(From Science).
(30 November 2005)
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
(From Science).
(23 November 2005)
Twists in the Tale of the Aging Yeast
(From Science).
(23 November 2005)
Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake
(From Science).
(16 November 2005)
Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance
(From Science).
(2 November 2005)
The
Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS
(From Science).
(19 October 2005)
Keeping the Young from Dying Old
(From ScienceNow).
(31 August 2005)
Suppression of Aging in Mice by the Hormone Klotho
(From Science).
(31 August 2005)
Preventing Alzheimer's: A Lifelong Commitment?
(From Science).
(10 August 2005)
HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction
(From Science).
(3 August 2005)
Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
(From Science).
(27 July 2005)
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
(From Science).
(20 July 2005)
Patient-Specific Embryonic Stem Cells Derived from Human SCNT Blastocysts
(From Science).
(25 May 2005)
Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
(From Science).
(11 May 2005)
Complement Factor H Polymorphism in Age-Related Macular Degeneration
(From Science).
(16 March 2005)
Complement Factor H Polymorphism and Age-Related Macular Degeneration
(From Science).
(16 March 2005)
Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration
(From Science).
(16 March 2005)
Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance
(From Science).
(9 February 2005)
Self-Propagating, Molecular-Level Polymorphism in Alzheimer's
Anticonvulsant Medications Extend Worm Life-Span
Results suggest that neural activity regulates aging (From Science).
(19 January 2005)
Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
(From Science).
(22 December 2004)
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
(From Science).
(22 December 2004)
Defective Telomere Lagging Strand Synthesis in Cells Lacking WRN Helicase Activity
Loss of telomeres from single sister chromatids occurs in Werner syndrome cells. (From Science).
(15 December 2004)
Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis
(From Science).
(1 December 2004)
COX-2 Derived Prostacyclin Confers Atheroprotection on Female Mice
Inhibitors of COX-2 might increase the susceptibility of premenopausal females to cardiovascular disease. (From Science).
(24 November 2004)
Harnessing Chaperones to Generate Small-Molecule Inhibitors of Amyloid
A Cluster of Metabolic Defects Caused by Mutation in a Mitochondrial tRNA
Finding might have implications for understanding why hypertension and dyslipidemia often occur together. (From Science).
(27 October 2004)
Inflammatory Exposure and Historical Changes in Human Life-Spans
Reduced inflammation early in life might result in decreased mortality in old age. (From Science).
(22 September 2004)
Living with the Past: Evolution, Development, and Patterns of Disease
The risk of developing certain chronic diseases in adulthood might be affected by environmental influences early in life. (From Science).
(22 September 2004)
Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
(From Science).
(18 August 2004)
NAD to the Rescue
(From Science).
(18 August 2004)
Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body
Transcription factor lengthens life span and slashes fecundity in female flies. (From Science).
(16 June 2004)
Locating a New Step in Pain's Pathway
(From Science).
(12 May 2004)
S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function
New research reveals links between parkin modification, ubiquitination, and neurodegeneration. (From Science).
(28 April 2004)
Renovating the Heart
(From Science).
(21 April 2004)
ABAD Directly Links A
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
(From Science).
(21 April 2004)
Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells
It's not the vascular smooth muscle cells that enhance neuron production. (From Science).
(7 April 2004)
Nanos Maintains Germline Stem Cell Self-Renewal by Preventing Differentiation
Translational repressor prevents precocious entry into oogenesis. (From Science).
(31 March 2004)
Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice
(From Science).
(24 March 2004)
Aging Research's Family Feud
(From Science).
(3 March 2004)
Is Biomedical Research Too Dangerous to Pursue?
One bioethicist says no. (From Science).
(25 February 2004)
Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase
Insulin signaling pathway sensors influence longevity in mammals. (From Science).
(25 February 2004)
Respect Thy Neighbor!
Tissue microenvironment alters surrounding tumor cells. (From Science).
(11 February 2004)
Yeast Genes That Enhance the Toxicity of a Mutant Huntingtin Fragment or Alpha-Synuclein
(From Science).
(10 December 2003)
Insulin Signaling in Health and Disease
(From Science).
(10 December 2003)
Redox Regulation of Germline and Vulval Development in Caenorhabditis elegans
(From Science).
(10 December 2003)
Yeast Cells Provide Insight into Alpha-Synuclein Biology and Pathobiology
(From Science).
(10 December 2003)
Brain Researchers Try to Salvage Estrogen Treatments
(From Science).
(19 November 2003)
The Great Estrogen Conundrum
(From Science).
(19 November 2003)
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Common nonsteroidal anti-inflammatory drug reverses damage caused by neuroinflammation. (From Science).
(19 November 2003)
Yeast Life Span Extension by Calorie Restriction Is Independent of NAD Fluctuation
Alterations in cofactor concentrations don't affect Sir2 deacetylase activity. (From Science).
(12 November 2003)
CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
(From Science).
(8 October 2003)
Untangling Desmosomal Knots with Electron Tomography
(From Science).
(8 October 2003)
Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice
(From Science).
(8 October 2003)
An Age-Induced Switch to a Hyper-Recombinational State
Scientists use yeast to study genomic instability as a function of age. (From Science).
(1 October 2003)
An Age of Instability
The increase in genetic instability in aging yeast cells is independent of life span determination. (From Science).
(1 October 2003)
It's Never Too Late
Following a restricted diet during the golden years extends longevity. (From Science).
(24 September 2003)
Transcriptional Repression of Atherogenic Inflammation: Modulation by PPAR
Autophagy Genes Are Essential for Dauer Development and Life Span Extension in C. elegans
Life span extension and dauer development require autophagy. (From Science).
(10 September 2003)
Possible Role for Environmental Copper in Alzheimer's Disease
(From Science).
(20 August 2003)
Drug Deals Diabetes a One-Two Punch
(From Science).
(23 July 2003)
Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a
(From Science).
(16 July 2003)
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
(From Science).
(2 July 2003)
Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor
(From Science).
(2 July 2003)
Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
Antimicrobial and anti-aging might go hand in hand. (From Science).
(25 June 2003)
Senescence in a Bacterium with Asymmetric Division
For senescence to evolve, asymmetry is key. (From Science).
(25 June 2003)
Old Neurons Revisit Their Youth
GABA restores sensory function in mature monkeys. (From Science).
(7 May 2003)
Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein
Coincubation of proteins synergistically promotes amyloid fibril production in vitro. (From Science).
(7 May 2003)
Lamin A Truncation in Hutchinson-Gilford Progeria
Long-sought mutation leads to loss of lamin A expression. (From Science).
(7 May 2003)
Europe's Population at a Turning Point
If the low birthrate trend continues, the number of inhabitants of the Continent will shrink significantly. (From Science).
(2 April 2003)
A Matter of Life or Death
New insight into causes of blindness. (From Science).
(19 March 2003)
Drosophila BLM in Double-Strand Break Repair by Synthesis-Dependent Strand Annealing
Blm blocks patching by error-prone pathways. (From Science).
(15 January 2003)
Newborn Neurons Search for Meaning
Scientists have established that these cells exist--but no one's sure what they do. (From Science).
(8 January 2003)
Sex Differences in Mortality Rate
Men more susceptible than women to parasite-induced death. (From Science).
(25 September 2002)
A Cinderella Caspase Takes Center Stage
Caspase-2 has a starring role in triggering apoptosis. (From Science).
(28 August 2002)
Protecting the Brain While Killing Pain?
An aspirin a day might keep Alzheimer's away. (From Science).
(28 August 2002)
New Alzheimer's Treatments That May Ease the Mind
As researchers come to better understand their foe, they're devising more means of attacking it. (From Science).
(28 August 2002)
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
(From Science).
(24 July 2002)
A Generation Gap in Brain Activity
As we age, we're no longer in our right hemisphere. (From Science).
(26 June 2002)
Regulation of Hypoxic Death in C. elegans by the Insulin/IGF Receptor Homolog DAF-2
Response to hypoxia shares signaling components with pathways governing stress resistance and life-span determination. (From Science).
(19 June 2002)
Premature Aging in Mice Deficient in DNA Repair and Transcription
Support for the DNA damage accumulation hypothesis. (From Science).
(17 April 2002)
Protein Structure: Harmless Proteins Twist Into Troublemakers
(From Science).
(10 April 2002)
Redox Regulation of Forkhead Proteins Through a p66shc-Dependent Signaling Pathway
Disparate findings come together. (From Science).
(13 March 2002)
Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans
(From Science).
(23 January 2002)
Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q
(From Science).
(9 January 2002)
ATR and ATRIP: Partners in Checkpoint Signaling
(From Science).
(28 November 2001)
A DNA Microarray-Based Genetic Screen for Nonhomologous End Joining Mutants in Saccharomyces cerevisiae
Seek and ye shall find new pathway components. (From Science).
(14 November 2001)
CNS Synaptogenesis Promoted by Glia-Derived Cholesterol
Much-maligned molecules promote mature synapse formation. (From Science).
(14 November 2001)
Kinetic Stabilization of the
Dopamine May Sustain Toxic Protein
(From Science).
(14 November 2001)
Dopamine's Reversal of Fortune
Transporters pull double duty. (From Science).
(10 October 2001)
Strand-Specific Postreplicative Processing of Mammalian Telomeres
A telomere is not a telomere is not a telomere. (From Science).
(10 October 2001)
Trans-Suppression of Misfolding in an Amyloid Disease
Stabilizing subunits may protect against amyloidosis. (From Science).
(10 October 2001)
DNA Ends RecQ-uire Attention
Helicase defects spur cancer and premature-aging syndromes. (From Science).
(10 October 2001)
Hints of a "Master Gene" for Extreme Old Age
Blasting past 90 with a genetic booster rocket? (From Science).
(10 October 2001)
Human DNA Repair Genes
A panoply of proteins protects DNA. (From Science).
(10 October 2001)
Growing Old Together
Common processes control life-span in model organisms. (From Science).
(10 October 2001)
Do Mitochondrial Mutations Dim the Fire of Life?
Pulling the plug on the cell's power plant. (From Science).
(10 October 2001)
Parkin and Its Substrates
Toxic
Tauists and
Sardinia's Mysterious Male Methuselahs
La Dolce Vita. (From Science).
(10 October 2001)
Aging, Chromatin, and Food Restriction
Connecting the dots. (From Science).
(10 October 2001)
A Portrait of Alzheimer Secretases
New Features and Familiar Faces. (From Science).
(10 October 2001)
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikk
A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function
Short flies, long lives. (From Science).
(3 October 2001)
Extended Life-Span Conferred by Cotransporter Gene Mutations in Drosophila
Genetic caloric restriction? (From Science).
(3 October 2001)
Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
Oh what a tangled web is weaved. (From Science).
(3 October 2001)
Regulation of Longevity and Stress Resistance by Sch9 in Yeast
Rising to the challenges of old age. (From Science).
(3 October 2001)
Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by A
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
A long-term buzz. (From Science).
(3 October 2001)
|
-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's Models
(From Science).
(28 June 2006)
-Glucuronidase Klotho Hydrolyzes and Activates the TRPV5 Channel
Potential antiaging hormone affects calcium channel activity (From Science).
(26 October 2005)
Deletion of PPAR
Science of Aging Knowledge Environment. ISSN 1539-6150
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