There are nine parts to this page: About Science's SAGE KE, The SAGE KE Logo, SAGE KE Editorial Staff, Executive Scientific Advisory Board, Extended Scientific Advisory Board, Curator, Genes/Interventions Database, Coordinator, Neurodegenerative Disease Case Studies, and Contributing Editors.

About Science's SAGE KE

Knowledge is of two kinds. We know a subject ourselves, or we know where we can find information on it. --Samuel Johnson

Welcome to Science's SAGE KE, an online resource for researchers in the field of aging. Our mission is threefold: to deliver high-quality information about aging and related disciplines; to provide tools for more efficient searching and information retrieval; and to create a setting where researchers feel encouraged to share data and engage in discussion. Because SAGE KE can be accessed from your desktop, it has the potential to change the way you stay abreast of current research and events, and collaborate with other researchers from around the world.

We strive to cover advances on basic mechanisms of aging and age-related diseases rather than purely clinical research. In addition, we endeavor to alert our community to developments in areas that are highly relevant for research on aging, such as new methods for single cell analysis of gene expression and major findings on DNA repair, mitochondrial biology, chromatin modification, protein turnover, somatic mutation, etc.

Science's SAGE KE is the third in a series of Knowledge Environments developed by Science and AAAS, following the Signal Transduction Knowledge Environment (STKE) and AIDScience. Because of the vast breadth of the "aging" field, AAAS felt that this research area was an ideal focus for its third Knowledge Environment. This field includes a wide variety of researchers working on diverse biological processes in numerous species. There is no single meeting that all researchers in the field of aging attend, nor is there any one journal in which everyone publishes. SAGE KE offers an opportunity to create a virtual community where investigators in the field can come together for information exchange and discussion. AAAS received funding for SAGE KE from the Ellison Medical Foundation.

The SAGE KE Logo

In Chinese Buddhism, the lotus or sea rose symbolizes both immortality and purity. The fruit, flower, and stalk of the plant represent the past, present, and future. In SAGE KE's logo, the flower is in full bloom. The bursting petals and leaves encircle a face to illustrate human life at its fullest potential--pushing mortality to its limits. The design also embodies the notion of a pure existence, of living in the best way possible. --Description by Jennifer Toy

SAGE KE Editorial Staff

George M. Martin, Editor-in-Chief; Professor of Pathology Emeritus (Active), Adjunct Professor of Genome Sciences (Retired), and Director Emeritus of the Alzheimer's Disease Research Center, University of Washington, Seattle, WA. E-mail:

Evelyn Strauss, Ph.D., Senior News Editor. E-mail:

Heather McDonald, Ph.D., Associate Editor. E-mail:

Mitchell Leslie, M.A., Contributing Writer. E-mail:

Executive Scientific Advisory Board

Steven Austad, Professor, University of Texas Health Science Center, San Antonio, TX.

Judith Campisi, Head of the Department of Cell and Molecular Biology Life Sciences Division, Lawrence Berkeley National Laboratories, Berkeley, CA.

Leonard P. Guarente, Novartis Professor of Biology, Massachusetts Institute of Technology, Cambridge, MA.

Cynthia J. Kenyon, Herbert Boyer Professor of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA.

Richard A. Miller, Professor of Pathology and Associate Director for Research, University of Michigan Geriatrics Center, Ann Arbor, MI.

Arlan G. Richardson, Director, Aging Research and Education Center, Senior Research Career Scientist, The University of Texas Health Science Center at San Antonio, San Antonio, Texas.

Phyllis M. Wise, Ph.D., Dean, Division of Biological Sciences, University of California Davis, Davis, CA.

Extended Scientific Advisory Board

Rudi Balling, Director, Institute of Mammalian Genetics, Head, Developmental Genetics Group, GSF-Neuherberg, Germany.

Etienne-Emile Baulieu, INSERM and Collège de France, and Vice President, French Academy of Sciences.

Mark Beers, Executive Director of Geriatrics and Medical Literature, and Editor-in-Chief of the Merck Manuals, Merck & Co.

R�jean H�bert, Scientific Director, Institute of Aging,Canadian Institutes of Health Research, Canada.

Masao Ito, Director, RIKEN Brain Science Institute, Saimata, Japan.

Tom Kirkwood, Professor and Head, Department of Gerontology, University of Newcastle Upon Tyne, Newcastle, U.K.

Eline Slagboom, Department of Vascular and Connective Tissue Research, TNO-PG Gaubius Laboratory Leiden, Leiden, The Netherlands.

Curator, Genes/Interventions Database

Matt Kaeberlein, University of Washington

Coordinator and Contributing Editor, Neurodegenerative Disease Case Studies

Karen Marder, College of Physicians and Surgeons, Columbia University, and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY.

Contributing Editors

Rudi Balling, German Research Centre for Biotechnology

Nir Barzilai, Albert Einstein College of Medicine

Ralf Baumeister, Albert-Ludwigs-University of Freiburg

Sascha Beneke, University of Konstanz

Alexander B�rkle, University of Konstanz

Ana Maria Cuervo, Albert Einstein College of Medicine

Mark D'Esposito, University of California, Berkeley

Laura Dugan, University of California, San Diego

Jay Edelberg, Weill Medical College of Cornell University

Ari Gafni, University of Michigan

Douglas Gray, Ottawa Regional Cancer Centre

Qing Guo, University of Oklahoma Health Sciences Center

Roger Hajjar, MGH, Harvard Medical School

Joshua Hare, Johns Hopkins School of Medicine

Maren Hertweck, Albert-Ludwigs-University of Freiburg

Steve Helfand, University of Connecticut Health Center

Russell Hepple, University of Calgary

Fuki Hisama, Yale School of Medicine

Laura Mays Hoopes, Pomona College

Bradley Hyman, MGH, Harvard Medical School

Yves Joanette, Université de Montréal

Abdel Khalil, Université de Sherbrooke, Québec

Bruce Kristal, Cornell University Medical College

Pamela Larsen, University of California, Los Angeles

Richard Loeser, The Rush Arthritis and Orthopedics Institute

Valter Longo, University of Southern California

Christopher MacKnight, Dalhousie University

Estella Medrano, Baylor University

Simon Melov, Buck Institute

Vincent Monnier, Case Western Reserve University

Gerd Multhaup, Freie Universit�t Berlin

Almut Nebel, Christian-Albrechts-University

Susanne Nikolaus, Christian-Albrechts-University

Anne Louise Oaklander, Harvard Medical School

Lina Obeid, Medical University of South Carolina

Heinz D. Osiewacz, J. W. Goethe University

Graham Pawelec, University of T�bingen

Domenico Pratic�, University of Pennsylvania

Daniel Promislow, University of Georgia

Thomas Rando, Stanford University

May Reed, University of Washington

Karl Riabowol, University of Calgary

Ulrich Roters, IWF Knowledge and Media, G�ttingen

Stefan Schreiber, Christian-Albrechts-University

Klaus Schughart, German Research Centre for Biotechnology

Norman Sharpless, University of North Carolina School of Medicine

David Sinclair, Harvard Medical School

Mark Smith, Case Western Reserve University

Dietmar Thal, University of Bonn Medical Center

Marc Tatar, Brown University

Jonathan L. Tilly, MGH, Harvard Medical School

Mitch Turker, Oregon Health Sciences University

Daniela Vogt-Weisenhorn, GSF-Forschungszentrum Neuherberg

Jeremy Walston, Johns Hopkins

Evi Wollscheid-Lengeling, German Research Centre for Biotechnology

Wolfgang Wurst, GSF-Forschungszentrum Neuherberg

Raymond Yung, University of Michigan Medical Center

Science of Aging Knowledge Environment. ISSN 1539-6150