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Ames Dwarf
Prop-1 encodes a 226-amino acid, soluble protein, a transcription factor involved in embryonic development of the pituitary gland.
(3 October 2001)
Sci. SAGE KE 2001 (1), tg11.
Amyloid Precursor Protein (APP) E693Q Transgenic Mice (APPDutch Mice)
This strain is a model for hereditary cerebral hemorrhage with amyloidosis.
(27 October 2004)
Amyloid Precursor Protein (APP) Transgenic Mice (Tg2576 Mice)
Lipid peroxidation in the brains of young animals might foreshadow beta-amyloid deposition in the brains of old animals in this model of Alzheimer's disease.
(4 February 2004)
Apolipoprotein E4 Mice
Mice that carry the human apoE4 gene display impairments in learning, memory, and exploratory behavior.
(29 October 2003)
atm-/- Strain 1
The atm gene encodes a member of the phosphatidylinositol 3-kinase-related kinase family. Mice deficient in a functional version of the atm protein are considered to be a paradigm of ataxia telangiectasia.
(3 October 2001)
atm-/- Strain 2
The atm gene encodes a member of the phosphatidylinositol 3-kinase-related kinase family. Mice deficient in a functional version of the atm protein are considered to be a paradigm of ataxia telangiectasia.
(3 October 2001)
atm-/- Strain 3
The atm gene encodes a member of the phosphatidylinositol 3-kinase-related kinase family. Mice deficient in a functional version of the atm protein are considered to be a paradigm of ataxia telangiectasia.
(3 October 2001)
BRI-A
BRI-A
CB1 Knockout Mice
Cannabinoid receptors are involved in the control of bone mass and osteoclast activity.
(15 June 2005)
Copper, Zinc Superoxide Dismutase
Cu,Zn-SOD is the major cellular form of superoxide dismutase; it is encoded by the Sod1 gene. Cu,Zn-SOD catalyses the conversion of superoxide (O2-) to hydrogen peroxide (H2O2) and dioxygen (O2).
(31 October 2001)
DJ-1–/– Mice
Mouse model of Parkinson's disease suggests that DJ-1 protects neurons from oxidative stress.
(20 April 2005)
Endothelin-Converting Enzyme Knockout Mice
ECE-/- mice have extra amyloid beta peptide in the brain.
(11 December 2002)
Ercc1–/– Mice (Ercc1tm1Dwm Mice)
ERCC1 functions in nucleotide excision repair and recombination repair.
(7 April 2004)
Gdf5-Cre/BmpR1afloxP Mice
This strain serves as a model of osteoarthritis.
(15 December 2004)
Glutamate-Cysteine Ligase Modifier Knockout Mice
Tissues retain reduced amounts of glutathione, and cells show increased sensitivity to peroxide.
(6 November 2002)
Growth Hormone Receptor Knockout (Laron) Mice
Growth hormone receptor is a 638-amino acid (precursor) transmembrane protein that binds to growth hormone (GH).
(27 February 2002)
Harlequin (Hq) Mice
AIF is a flavoprotein normally confined to the intermembrane space of the mitochondrion, where it is a free radical scavenger.
(25 September 2002)
Igf1r+/- Mice
Igf1r+/- mice live longer than their control littermates.
(26 February 2003)
Klotho Mice
The phenotype of Klotho mice shares similarity with some aspects of age-related human disorders.
(3 October 2001)
Ku70-/-
Ku70 is a 608-amino acid polypeptide and is a member of the adenosine triphosphate (ATP)-dependent, DNA helicase II, 70-kD subunit family thought to be involved in DNA repair and/or transposition.
(10 April 2002)
Ku80-/-
The 80-kD subunit of the Ku autoantigen is part of a heterodimer that contributes to genetic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end-joining pathway.
(10 April 2002)
Little Mice
Little mice lack a fully functional growth hormone-releasing hormone receptor (GHRHr), a 423-amino acid protein that binds to GHRH and induces growth hormore (GH) secretion.
(24 October 2001)
Liver-Specific IGF-1-Deficient Mice
IGF-1 is a regulator of somatic growth and cellular proliferation, because it is an inducer of the phosphatidylinositol 3-kinase survival pathway.
(23 October 2002)
Manganese Superoxide Dismutase (Mn SOD or Sod2)
SOD is a 75-amino acid (in mature form), soluble homotetrameric protein located in the mitochondrial matrix that catalyzes dismutation of O2- to H2O2 and O2.
(3 October 2001)
Myocyte-Specific Enhancer Factor 2A (MEF2A)-Deficient Mice
MEF2A is crucial for maintaining appropriate mitochondrial content and architectural integrity in the postnatal heart.
(16 October 2002)
NOS1-/- Mice
NOS1-/- mice exhibit insulin resistance in peripheral tissues.
(23 July 2003)
NOS3-/- Mice
NOS3-/- mice show insulin resistance and hypertension.
(23 July 2003)
p27Kip1-/- Strain 1
p27 is a 198-amino acid member of the Kip/Cip family of cyclin-CDK inhibitors. It binds to cyclin-CDK complexes and inhibits their kinase activity.
(3 October 2001)
p27Kip1-/- Strain 2
p27 is a 198-amino acid member of the Kip/Cip family of cyclin-CDK inhibitors. It binds to cyclin-CDK complexes and inhibits kinase activity.
(3 October 2001)
p27Kip1-/- Strain 3
p27 is a 198-amino acid member of the Kip/Cip family of cyclin-CDK inhibitors. It binds to cyclin-CDK complexes and inhibits kinase activity.
(3 October 2001)
p53 Knockout
The murine p53 gene encodes a 393-amino acid protein (p53), which has been studied primarily as a tumor suppressor.
(15 May 2002)
p57 Kip2-/- Strain 1
p57 is a member of the Kip/Cip family and contains a cyclin dependent kinase-inhibiting domain.
(3 October 2001)
p57 Kip2-/- Strain 2
p57 is a member of the Kip/Cip family and contains a cyclin dependent kinase-inhibiting domain.
(3 October 2001)
p57 Kip2-/- Strain 3
p57 is a member of the Kip/Cip family and contains a cyclin dependent kinase-inhibiting domain.
(3 October 2001)
p66Shc-/- Mice (Shc1tm1Pgp Mice)
p66Shc-/- (Shc1tm1Pgp) mice live longer than the wild type and are resistant to paraquat.
(26 February 2003)
Park2tm1Rpa Mice
Mice designed to model a heritable form of Parkinson's disease do not exhibit parkinsonism.
(9 March 2005)
PARP–/– Mice
PARP is an ADP-ribosyltransferase that functions in the posttranslational modification of nuclear proteins.
(7 April 2004)
Rtel–/– Mice
The Rtel gene encodes a helicase-like protein that functions in the regulation of telomere length.
(18 August 2004)
Snell Dwarf
Snell dwarf mice are phenotypically similar to Ames mice. The mutation causing the Snell phenotype is in the pit-1 gene.
(17 October 2001)
Telomerase RNA Component (Terc) Knockout Mice
Terc-/- mice have short telomeres and lack telomerase activity.
(26 February 2003)
Triple-Transgenic Alzheimer's Disease Model Mice
Studies of these mice support the amyloid cascade hypothesis for Alzheimer's disease pathology.
(13 August 2003)
Werner mouse K577M-WRN
The WRN protein is a member of the RecQ-like subfamily of DNA helicases.
(3 April 2002)
Werner mouse Wrn-null
The WRN protein is a member of the RecQ-like subfamily of DNA helicases.
(3 April 2002)
Werner mouse Wrn-
XPD (R722W) TTD
Mice with premature aging phenotypes are deficient in DNA repair and transcription.
(15 May 2002)
Zmpste24–/– Mice
Reducing prelamin A abundance abolishes progeria-like phenotypes.
(12 January 2005)
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40 Transgenic Mice
Mice that produce human Aß1-40 in the absence of human amyloid precursor protein production do not develop amyloid-related pathologies.
(10 August 2005)
hel
The WRN protein is a member of the RecQ-like subfamily of DNA helicases.
(3 April 2002)
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