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Ames Dwarf  Prop-1 encodes a 226-amino acid, soluble protein, a transcription factor involved in embryonic development of the pituitary gland.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg11.
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Amyloid Precursor Protein (APP) E693Q Transgenic Mice (APPDutch Mice)  This strain is a model for hereditary cerebral hemorrhage with amyloidosis.  (27 October 2004)
Sci. Aging Knowl. Environ. 2004 (43), tg5. [DOI: 10.1126/sageke.2004.43.tg5]
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Amyloid Precursor Protein (APP) Transgenic Mice (Tg2576 Mice)  Lipid peroxidation in the brains of young animals might foreshadow beta-amyloid deposition in the brains of old animals in this model of Alzheimer's disease.  (4 February 2004)
Sci. Aging Knowl. Environ. 2004 (5), tg1. [DOI: 10.1126/sageke.2004.5.tg1]
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Apolipoprotein E4 Mice  Mice that carry the human apoE4 gene display impairments in learning, memory, and exploratory behavior.  (29 October 2003)
Sci. SAGE KE 2003 (43), tg7. [DOI: 10.1126/sageke.2003.43.tg7]
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atm-/- Strain 1  The atm gene encodes a member of the phosphatidylinositol 3-kinase-related kinase family. Mice deficient in a functional version of the atm protein are considered to be a paradigm of ataxia telangiectasia.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg1.
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atm-/- Strain 2  The atm gene encodes a member of the phosphatidylinositol 3-kinase-related kinase family. Mice deficient in a functional version of the atm protein are considered to be a paradigm of ataxia telangiectasia.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg2.
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atm-/- Strain 3  The atm gene encodes a member of the phosphatidylinositol 3-kinase-related kinase family. Mice deficient in a functional version of the atm protein are considered to be a paradigm of ataxia telangiectasia.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg3.
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BRI-A{beta}40 Transgenic Mice   Mice that produce human Aß1-40 in the absence of human amyloid precursor protein production do not develop amyloid-related pathologies.  (10 August 2005)
Sci. Aging Knowl. Environ. 2005 (32), tg5. [DOI: 10.1126/sageke.2005.32.tg5]
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BRI-A{beta}42 Transgenic Mice   Mice that produce human Aß1-42 in the absence of human amyloid precursor protein production develop amyloid-related pathologies.  (10 August 2005)
Sci. Aging Knowl. Environ. 2005 (32), tg6. [DOI: 10.1126/sageke.2005.32.tg6]
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CB1 Knockout Mice  Cannabinoid receptors are involved in the control of bone mass and osteoclast activity.  (15 June 2005)
Sci. Aging Knowl. Environ. 2005 (24), tg4. [DOI: 10.1126/sageke.2005.24.tg4]
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Copper, Zinc Superoxide Dismutase  Cu,Zn-SOD is the major cellular form of superoxide dismutase; it is encoded by the Sod1 gene. Cu,Zn-SOD catalyses the conversion of superoxide (O2-) to hydrogen peroxide (H2O2) and dioxygen (O2).  (31 October 2001)
Sci. SAGE KE 2001 (5), tg15.
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DJ-1–/– Mice  Mouse model of Parkinson's disease suggests that DJ-1 protects neurons from oxidative stress.  (20 April 2005)
Sci. Aging Knowl. Environ. 2005 (16), tg3. [DOI: 10.1126/sageke.2005.16.tg3]
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Endothelin-Converting Enzyme Knockout Mice  ECE-/- mice have extra amyloid beta peptide in the brain.  (11 December 2002)
Sci. SAGE KE 2002 (49), tg13.
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Ercc1–/– Mice (Ercc1tm1Dwm Mice)  ERCC1 functions in nucleotide excision repair and recombination repair.  (7 April 2004)
Sci. Aging Knowl. Environ. 2004 (14), tg2. [DOI: 10.1126/sageke.2004.14.tg2]
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Gdf5-Cre/BmpR1afloxP Mice  This strain serves as a model of osteoarthritis.  (15 December 2004)
Sci. Aging Knowl. Environ. 2004 (50), tg6. [DOI: 10.1126/sageke.2004.50.tg6]
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Glutamate-Cysteine Ligase Modifier Knockout Mice  Tissues retain reduced amounts of glutathione, and cells show increased sensitivity to peroxide.  (6 November 2002)
Sci. SAGE KE 2002 (44), tg12.
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Growth Hormone Receptor Knockout (Laron) Mice  Growth hormone receptor is a 638-amino acid (precursor) transmembrane protein that binds to growth hormone (GH).  (27 February 2002)
Sci. SAGE KE 2002 (8), tg1.
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Harlequin (Hq) Mice  AIF is a flavoprotein normally confined to the intermembrane space of the mitochondrion, where it is a free radical scavenger.  (25 September 2002)
Sci. SAGE KE 2002 (38), tg9.
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Igf1r+/- Mice  Igf1r+/- mice live longer than their control littermates.  (26 February 2003)
Sci. SAGE KE 2003 (8), tg1.
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Klotho Mice  The phenotype of Klotho mice shares similarity with some aspects of age-related human disorders.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg4.
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Ku70-/-  Ku70 is a 608-amino acid polypeptide and is a member of the adenosine triphosphate (ATP)-dependent, DNA helicase II, 70-kD subunit family thought to be involved in DNA repair and/or transposition.  (10 April 2002)
Sci. SAGE KE 2002 (14), tg6.
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Ku80-/-  The 80-kD subunit of the Ku autoantigen is part of a heterodimer that contributes to genetic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end-joining pathway.  (10 April 2002)
Sci. SAGE KE 2002 (14), tg5.
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Little Mice  Little mice lack a fully functional growth hormone-releasing hormone receptor (GHRHr), a 423-amino acid protein that binds to GHRH and induces growth hormore (GH) secretion.  (24 October 2001)
Sci. SAGE KE 2001 (4), tg14.
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Liver-Specific IGF-1-Deficient Mice  IGF-1 is a regulator of somatic growth and cellular proliferation, because it is an inducer of the phosphatidylinositol 3-kinase survival pathway.  (23 October 2002)
Sci. SAGE KE 2002 (42), tg11.
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Manganese Superoxide Dismutase (Mn SOD or Sod2)  SOD is a 75-amino acid (in mature form), soluble homotetrameric protein located in the mitochondrial matrix that catalyzes dismutation of O2- to H2O2 and O2.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg12.
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Myocyte-Specific Enhancer Factor 2A (MEF2A)-Deficient Mice  MEF2A is crucial for maintaining appropriate mitochondrial content and architectural integrity in the postnatal heart.  (16 October 2002)
Sci. SAGE KE 2002 (41), tg10.
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NOS1-/- Mice  NOS1-/- mice exhibit insulin resistance in peripheral tissues.  (23 July 2003)
Sci. SAGE KE 2003 (29), tg5.
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NOS3-/- Mice  NOS3-/- mice show insulin resistance and hypertension.  (23 July 2003)
Sci. SAGE KE 2003 (29), tg6.
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p27Kip1-/- Strain 1  p27 is a 198-amino acid member of the Kip/Cip family of cyclin-CDK inhibitors. It binds to cyclin-CDK complexes and inhibits their kinase activity.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg8.
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p27Kip1-/- Strain 2  p27 is a 198-amino acid member of the Kip/Cip family of cyclin-CDK inhibitors. It binds to cyclin-CDK complexes and inhibits kinase activity.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg9.
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p27Kip1-/- Strain 3  p27 is a 198-amino acid member of the Kip/Cip family of cyclin-CDK inhibitors. It binds to cyclin-CDK complexes and inhibits kinase activity.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg10.
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p53 Knockout  The murine p53 gene encodes a 393-amino acid protein (p53), which has been studied primarily as a tumor suppressor.  (15 May 2002)
Sci. SAGE KE 2002 (19), tg7.
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p57 Kip2-/- Strain 1  p57 is a member of the Kip/Cip family and contains a cyclin dependent kinase-inhibiting domain.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg5.
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p57 Kip2-/- Strain 2  p57 is a member of the Kip/Cip family and contains a cyclin dependent kinase-inhibiting domain.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg6.
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p57 Kip2-/- Strain 3  p57 is a member of the Kip/Cip family and contains a cyclin dependent kinase-inhibiting domain.  (3 October 2001)
Sci. SAGE KE 2001 (1), tg7.
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p66Shc-/- Mice (Shc1tm1Pgp Mice)  p66Shc-/- (Shc1tm1Pgp) mice live longer than the wild type and are resistant to paraquat.  (26 February 2003)
Sci. SAGE KE 2003 (8), tg4.
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Park2tm1Rpa Mice  Mice designed to model a heritable form of Parkinson's disease do not exhibit parkinsonism.  (9 March 2005)
Sci. Aging Knowl. Environ. 2005 (10), tg2. [DOI: 10.1126/sageke.2005.10.tg2]
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PARP–/– Mice  PARP is an ADP-ribosyltransferase that functions in the posttranslational modification of nuclear proteins.  (7 April 2004)
Sci. Aging Knowl. Environ. 2004 (14), tg3. [DOI: 10.1126/sageke.2004.14.tg3]
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Rtel–/– Mice  The Rtel gene encodes a helicase-like protein that functions in the regulation of telomere length.  (18 August 2004)
Sci. Aging Knowl. Environ. 2004 (33), tg4. [DOI: 10.1126/sageke.2004.33.tg4]
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Snell Dwarf  Snell dwarf mice are phenotypically similar to Ames mice. The mutation causing the Snell phenotype is in the pit-1 gene.  (17 October 2001)
Sci. SAGE KE 2001 (3), tg13.
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Telomerase RNA Component (Terc) Knockout Mice  Terc-/- mice have short telomeres and lack telomerase activity.  (26 February 2003)
Sci. SAGE KE 2003 (8), tg2.
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Triple-Transgenic Alzheimer's Disease Model Mice  Studies of these mice support the amyloid cascade hypothesis for Alzheimer's disease pathology.  (13 August 2003)
Sci. SAGE KE 2003 (32), tg7. [DOI: 10.1126/sageke.2003.32.tg7]
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Werner mouse K577M-WRN  The WRN protein is a member of the RecQ-like subfamily of DNA helicases.  (3 April 2002)
Sci. SAGE KE 2002 (13), tg2.
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Werner mouse Wrn-null  The WRN protein is a member of the RecQ-like subfamily of DNA helicases.  (3 April 2002)
Sci. SAGE KE 2002 (13), tg3.
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Werner mouse Wrn-{Delta}hel  The WRN protein is a member of the RecQ-like subfamily of DNA helicases.  (3 April 2002)
Sci. SAGE KE 2002 (13), tg4.
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XPD (R722W) TTD  Mice with premature aging phenotypes are deficient in DNA repair and transcription.  (15 May 2002)
Sci. SAGE KE 2002 (19), tg8.
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Zmpste24–/– Mice  Reducing prelamin A abundance abolishes progeria-like phenotypes.  (12 January 2005)
Sci. Aging Knowl. Environ. 2005 (2), tg1. [DOI: 10.1126/sageke.2005.2.tg1]
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Science of Aging Knowledge Environment. ISSN 1539-6150